Forward Reaction Prediction: A helper for organic synthesis

Draw or paste your reactants; the model predicts the likely product(s). Output is rendered by RDKit.js directly from the model's raw SMILES (shown in green beneath each structure). Ketcher is used only for drawing input.

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Model:
Built on ReactionT5v2 (Sagawa & Kojima, J. Cheminform. 2025, doi:10.1186/s13321-025-01075-4, MIT-licensed), fine-tuned on Pistachio reaction data (NextMove Software). This web interface built independently.
Beam width: 10
Show top-k: 4


Test reactions: